منابع مشابه
BINDING OF NAPROXEN TO SERUM PROTEINS IN PATIENTS WITH LIVER CIRRHOSIS AND HEALTHY INDIVIDUALS
A three-fold decrease of the in vitro ability of serum proteins to bind naproxen was shown in patients with cirrhosis of the liver compared to healthy individuals. This decrease was caused by quantitative changes in serum proteins in the sera of patients with liver damage. Lower doses of naproxen are therefore suggested in the treatment of patients with liver dysfunction.
متن کاملDetermination of theophylline binding to human serum proteins by isotachophoresis.
Free theophylline was isolated from human serum by ultrafiltration and analysed in a leading electrolyte of 7.5 mM morpholinoethanesulphonic acid with ammediol as a counter ion at pH 8.90 and alpha-alanine as a terminator. The UV (280 nm) absorbance of the theophylline spike between serine and bicine as spacers was integrated. Binding percentages to human pool serum, human albumin and alpha 1-a...
متن کاملMyocardial stimulation by pancuronium bromide.
The effect of pancuronium bromide on the canine myocardium was studied by observing several indices of myocardial contractility during i.v. and intracoronary infusion of the drug in an anaesthetized, open-chested dog preparation. Pancuronium produced tachycardia when given for 2 min by i.v. and intracoronary infusion with the heart intact. Following denervation and pacing of the heart the intra...
متن کاملThyroxine-binding by Serum
The occurrence of hypercholesterolemia, lowered basal metabolic rate and depressed serum proteinbound iodine in the nephrotic syndrome has directed attention to the thyroid gland in this disorder. Although hypothyroidism has been suspected, these patients are usually considered, on clinical grounds, to be euthyroid, and they fail to respond in a specific manner to even large doses of thyroid ho...
متن کاملDifferentiating various abnormalities of thyroxin binding to serum proteins by radioelectrophoresis of thyroxin and immunoassay of binding proteins.
Using the simple method of protein analysis described here, we could identify thyroxin (T4)-binding-protein abnormalities in euthyroid patients with hyperthyroxinemia or hypothyroxinemia. Serum incubated with [125I]thyroxin was analyzed by agarose gel electrophoresis, with bromphenol blue staining of protein. The relative distribution of radioactive T4 was determined for each binding protein--t...
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ژورنال
عنوان ژورنال: Anaesthesia
سال: 1976
ISSN: 0003-2409,1365-2044
DOI: 10.1111/j.1365-2044.1976.tb11795.x